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A high throughput assay of the hepatitis C virus nonstructural protein 3 serine proteinase

โœ Scribed by Nobuko Kakiuchi; Satoshi Nishikawa; Masao Hattori; Kunitada Shimotohno


Book ID
114140763
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
99 KB
Volume
80
Category
Article
ISSN
0166-0934

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โœ Mauro Cerretani; Laura Di Renzo; Sergio Serafini; Alessandra Vitelli; Nadia Genn ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 127 KB

A novel radiometric in vitro assay for discovery of inhibitors of hepatitis C viral protease activity, suitable for high-throughput screening, was developed. The NS3 protein of hepatitis C virus (HCV) contains a serine protease, whose function is to process the majority of the nonstructural proteins