A high precision method for determination of differential titration curves of proteins using two glass electrodes

A pK determination method for proteins f

A pK determination method for proteins from titration curves using principle component analysis

✍ Jaesool Shim; Prashanta Dutta; Cornelius F. Ivory 📂 Article 📅 2008 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 968 KB

## Abstract Principal component analysis (PCA) technique is used for the precise determination of pK values from titration curves of amphoteric molecules, such as proteins and amino acids. A regression model is developed based on the effective charge of amphoteric molecules. Partial domain method,