A high phosphotyrosine phosphatase activity is present in differentiating bovine lens cells
✍ Scribed by Pierre R. Blanquet; Frederic Croquet
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 333 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
✦ Synopsis
Activity of phosphotyrosine ‐ protein phosphatases (PTPases) has been investigated in the different cellular regions of bovine eye lens. PTPases were tested in cellular detergent extracts using phospholabelled synthetic peptides and p‐nitrophenyl phosphate. We show that a high PTPase activity is only present in cells which undergo differentiation, namely the equatorial epithelium and cortex fiber cells. Since this activity is found to be severely inhibited by a specific inhibitor of receptor ‐ type PTPases, it can be suggested that one or more members of this class of PTPases might play an important role in the lens differentiation process.