A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish

Sox9, a key transcription factor of bone

Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

✍ Qiuhui Pan; Yongchun Yu; Qiongyu Chen; Chunsheng Li; Hong Wu; Yang Wan; Ji Ma; F 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

## Abstract Mouse embryonic fibroblasts (MEFs) can be differentiated into fully functional chondrocytes in response to bone morphogenetic protein‐2 (BMP‐2). The expression of Sox9, a critical transcription factor for the multiple steps of chondrogenesis, has been reported to be upregulated during t