Synthesis of δ-lactone, oxetane and azet
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Kathryn L. Thompson; Michael N. Chang; Yuan-Ching P. Chiang; Shu Shu Yang; John
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Article
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1991
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Elsevier Science
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French
⚖ 246 KB
A series of S-lactone (1 and Z), oxetane (3) and azetidinone (4 and 5) analogs were prepared from the HMG CoA synthase inhibitor L-659.699 ((E,E)-ll-[3'R-~ydymethyl)-4'-oxo-2'R-oxetanyl]-3,5,7Rtrimethyl-2,4-undecadienoic acid1v2), which maintained the truns relationship of the ring side chains. The