Pre-corekore mutants are frequently observed in patients with fulminant hepatitis. To investigate the extent of molecular characteristics of hepatitis B virus (HBV) genomes implicated in the development of fulminant hepatitis, fulllength HBV genomes were sequenced directly from sera of two patients
A Hepatitis B Virus Mutant Associated with an Epidemic of Fulminant Hepatitis
β Scribed by Liang, T. Jake; Hasegawa, Kiyoshi; Rimon, Nurit; Wands, Jack R.; Ben-Porath, Edna
- Book ID
- 126865694
- Publisher
- Massachusetts Medical Society
- Year
- 1991
- Tongue
- English
- Weight
- 812 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0096-6762
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A variant of hepatitis B virus has been described recently in HBsAg+ Mediterranean patients who lack HBeAg and who have an unusual and severe form of chronic hepatitis. This variant is unable to produce HBeAg because of the presence of a novel translational stop codon at the end of the precore regio
Hepatitis B virus (HBV) core promoter mutations have been implicated in the pathogenesis of fulminant hepatitis B. Due to the limited availability of primary human hepatocytes, the functional characterization of HBV mutants has been performed predominantly in transformed cells, which may not represe