A hemodynamic model for anaphylactic shock

✍ Scribed by WG Barsan; JR Hedges; S Syverud; WC Dalsey

• Book ID: 104312735
• Publisher: Elsevier Science
• Year: 1984
• Tongue: English
• Weight: 299 KB
• Volume: 13
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(84)80168-7

✦ Synopsis

We examined the effect of moderate fluid loading during electrically induced ventricular fibrillation (VF) and CPR in 18 dogs {12-26 kg). Oxygen uptake was measured with a modified recording spirometer. Blood flows were measured with tracer microspheres (15 -+ 0.9~ dia) at 5, 13, and 20 min after the initiation of VF and CPR. After 10 min of CPR, 9 dogs received a rapid infusion (11 mL/kg IV} of whole blood and 9 dogs received Ringer's. Differences between the blood-and the Ringer's-treated groups were not significant for any of the measured variables. However, some effects of fluid loading were significant. After fluid loading, cardiac output (CO) increased 34% (at 13 min) and then decreased (at 20 rain) to 84% of the control (5 rain) value. Despite the increase in CO, left ventricular (LV) perfusion fell to 74% of control after fluid loading, while brain flow decreased to 65% of control. At 20 rain (10 min after fluid loading), CO and brain flow returned to near control value, while LV flow remained low. Oxygen uptake was not significantly affected by fluid loading with either whole blood or Ringer's.