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A hantzsch 1,4-dihydropyridine synthesis producing an unusual by-product

โœ Scribed by J. W. Patterson; J. T. Nelson

Book ID
112128807
Publisher
Journal of Heterocyclic Chemistry
Year
1988
Tongue
English
Weight
206 KB
Volume
25
Category
Article
ISSN
0022-152X

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A novel TMSI-mediated synthesis of Hantz
A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature
โœ Gowravaram Sabitha; G.S.Kiran Kumar Reddy; Ch.Srinivas Reddy; J.S. Yadav ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 286 KB

The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature in the presence of iodotrimethylsilane (TMSI) generated in situ in CH 3 CN, in excellent yields.