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A Greener Approach for the Large-Scale Synthesis of 1,4,5-Trisubstituted Pyrazole, AZD8329

✍ Scribed by Rangappa, Paramashivappa; Ghosh, Avipsa; Chitrapadi, Smitha; Kantikar, Gajanan; CH, Vinod Kumar; Sythana, Sureshkumar; Manjunath, Sulur G; Nambiar, Sudhir; R, Sridhran


Book ID
125495255
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
367 KB
Volume
18
Category
Article
ISSN
1083-6160

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A one-pot process for the regioselective
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This Letter reports a facile and regioselective one-pot synthesis of 1,3,4-trisubstituted-1H-pyrazoles. It comprises a three-step telescoped sequence, which has been utilised in the production of a variety of differentially substituted pyrazoles.

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