A granuloma annulare-like eruption associated with the use of amlodipine

✍ Scribed by Adrian C Lim; Kim Hart; Dédée Murrell

• Book ID: 104469114
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 211 KB
• Volume: 43
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.2002.00547.x

✦ Synopsis

SUMMARY

A granuloma annulare‐like drug reaction is a rarely encountered clinical entity. A 64‐year‐old Caucasian female developed a granuloma annulare‐like reaction 13 days after starting amlodipine and cleared within 3 months after drug cessation. The eruption consisted of multiple erythematous pruritic papules, distributed symmetrically over the lateral aspects of the legs and thighs, as well as on both palms. Histology showed focal collagen degeneration and significant interstitial histiocytic dermal infiltrate suggestive of granuloma annulare. We review previously reported cases of granuloma annulare‐like drug reactions, in the context of a recently proposed classification for drug‐induced interstitial granulomatous reactions.