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A Glycine Site Associated with N-Methyl-d-Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists

✍ Scribed by M. Kessler; T. Terramani; G. Lynch; M. Baudry


Book ID
111175032
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
971 KB
Volume
52
Category
Article
ISSN
0022-3042

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## Abstract Syntheses of a series of enantiomerically pure, substituted analogues 7b–t of SDZ EAB 515 (7a) were described (__Schemes 1__ and __2__). Affinites for the NMDA receptor were measured ([^3^H]CGP‐39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional t