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A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure

โœ Scribed by Amruta A. Jambekar; Elena Palma; Luca Nicolosi; Andrea Rasola; Valeria Petronilli; Federica Chiara; Paolo Bernardi; Richard Needleman; William S. A. Brusilow


Book ID
111239564
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
610 KB
Volume
31
Category
Article
ISSN
0106-9543

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Iron chelation attenuates intracranial p
โœ Nikolaos Arkadopoulos; Demetrios Vlahakos; Georgia Kostopanagiotou; Dimitrios Pa ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 250 KB

Oxidative mechanisms have been implicated in the pathogenesis of brain edema in acute liver failure (ALF). The aim of this study was to test the hypothesis that inhibition of iron-catalyzed oxidative reactions through iron chelation using deferoxamine could attenuate brain edema in a swine model of