A glimpse of future hepatitis C virus treatment paradigms

✍ Scribed by Norah Terrault; Mandana Khalili

• Book ID: 102242308
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 74 KB
• Volume: 51
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.23523

✦ Synopsis

infection in the setting of a low to moderate body iron burden. However, for many modern-day liver diseases, the outcome may not always be as beneficial. The available data suggest that in the setting of abundant body iron, ER stress due to chronic diseases like NAFLD may result in a hepcidin-mediated redistribution of iron to reticuloendothelial cells, where it may further stimulate an immune response and exacerbate the disease. Additional research is needed to evaluate this extension of the exciting finding by Vecchi et al., but it is interesting to speculate that what may have once been a powerful weapon now looks more like a painful traitor in the liver's battle against chronic disease.