✦ LIBER ✦

A gleason score of 7 predicts a worse outcome for prostate carcinoma patients treated with radiotherapy

✍ Scribed by Garth A. Green; Alexandra L. Hanlon; Tahseen Al-Saleem; Gerald E. Hanks

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 94 KB
Volume: 83
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980901)83:5<971::aid-cncr24>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

In most reported surgical series, prostate carcinoma patients with a Gleason score of 7 have had worse outcomes than those with other moderately differentiated cancers. Because of variations in reporting grade and grouping Gleason scores, radiation series have conflicting results.

METHODS.

Five hundred sixty-three men with clinical Stage T1-T3, N0 or Nx, M0 adenocarcinoma of the prostate and known pretreatment prostate specific (PSA) levels received external beam radiation only. The median pretreatment PSA was 10.3 ng/mL (range, 0.2-191 ng/mL). The median duration of follow-up was 42 months (range, 2-114 months). Survival without biochemical failure (bNED) was defined as PSA Յ1.5 ng/mL and not rising when measured on two consecutive occasions.

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