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A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

✍ Scribed by Broderick, Peter; Carvajal-Carmona, Luis; Pittman, Alan M; Webb, Emily; Howarth, Kimberley; Rowan, Andrew; Lubbe, Steven; Spain, Sarah; Sullivan, Kate; Fielding, Sarah

Book ID: 109914245
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 239 KB
Volume: 39
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng.2007.18

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## Abstract Common single nucleotide polymorphisms (SNPs) in __SMAD7__ (18q21) have been linked to colorectal cancer (CRC) risk in genome‐wide association studies, but little is known about their effects on survival. SMAD7 regulates gastrointestinal inflammation by inhibiting transforming growth fa