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A genome screen for linkage disequilibrium inHLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers

✍ Scribed by Rene Goedde; Stephen Sawcer; Stefan Boehringer; Bianca Miterski; Eckhart Sindern; Michael Haupts; Sebastian Schimrigk; Alastair Compston; Joerg T. Epplen


Publisher
Springer
Year
2002
Tongue
English
Weight
226 KB
Volume
111
Category
Article
ISSN
0340-6717

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Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a complex genetic background. In order to identify loci associated with the disease, we had performed a genome screen initially using 6000 microsatellite markers in pooled DNA samples of 198 MS patients and 198 con