A genome scan of neuroticism in nicotine dependent smokers

✍ Scribed by Benjamin M. Neale; Patrick F. Sullivan; Kenneth S. Kendler

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 86 KB
• Volume: 132B
• Category: Article
• ISSN: 1552-4841
• DOI: 10.1002/ajmg.b.30095

✦ Synopsis

Abstract

Neuroticism is a personality factor that has consistently been demonstrated to be associated with anxiety, depression, and other “internalizing” disorders. We analyzed a genome scan for neuroticism on a sample of 129 sib‐pair families (113 with a single sibling pair, 18 with multiple sibling pairs) containing a total of 201 possible sibling pairs, ascertained for concordance on nicotine dependence. Using Merlin‐Regress, we replicated peaks for neuroticism described by prior studies, on chromosomes 1 and 11 with LOD scores of 2.52 and 1.97 (P‐value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P‐value of 0.0014). © 2004 Wiley‐Liss, Inc.