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A genetic variant in microRNA target site of TGF-β signaling pathway increases the risk of colorectal cancer in a Chinese population

✍ Scribed by Gong, Jing; Shen, Na; Zhang, Hong-Mei; Zhong, Rong; Chen, Wei; Miao, Xiaoping; Guo, An-Yuan


Book ID
121437390
Publisher
S. Karger AG
Year
2013
Tongue
English
Weight
176 KB
Volume
35
Category
Article
ISSN
1010-4283

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## Abstract Interleukin 1β (IL‐1β) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T‐31C and C‐511T) in the __IL‐1__β gene promote