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A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies

✍ Scribed by Ariel Brautbar; Lisa A. Pompeii; Abbas Dehghan; Julius S. Ngwa; Vijay Nambi; Salim S. Virani; Fernando Rivadeneira; André G. Uitterlinden; Albert Hofman; Jacqueline C.M. Witteman; Michael J. Pencina; Aaron R. Folsom; L. Adrienne Cupples; Christie M. Ballantyne; Eric Boerwinkle


Book ID
118424163
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
157 KB
Volume
223
Category
Article
ISSN
0021-9150

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Family history of coronary heart disease (CHD) has been found to be a risk factor for CHD in numerous studies. Few studies have addressed whether a quantitative measure of family history of CHD (family risk score, FRS) predicts CHD in African Americans. This study assessed the association between FR