A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease
β Scribed by Z.L. Awdeh; Edmond J. Yunis; Mark J. Audeh; Dolores Fici; Alberto Pugliese; Charles E. Larsen; Chester A. Alper
- Book ID
- 116614034
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 167 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0896-8411
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This study evaluates the cumulative incidence of Type 1 (insulin-dependent) diabetes mellitus in male army conscripts 0-18 (inclusive) years of age in the Netherlands (birth cohorts) over 10 years. Data from 2136 cases were retrieved from files of the conscript registry of the Royal Dutch Army. Asce
A combination of genetic and environmental factors is most likely the cause of Type 1 diabetes. Results from twin data, familial clustering of the disease and difference in incidence according to ethnicity infer the presence of specific disease genes. The genetic component of Type 1 diabetes cannot