𝔖 Bobbio Scriptorium
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A GENERALIZED MICHAELIS–MENTEN RESPONSE SURFACE

✍ Scribed by KATHRYN HIRST; GARY O. ZERBE; WILLIAM W. HAY JR.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
634 KB
Volume
15
Category
Article
ISSN
0277-6715

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✦ Synopsis

We describe an application of recently developed generalized Michaelis-Menten response surface and non-linear mixed model methodologies to model glucose utilization in foetal sheep. More specifically, we model the response surface of glucose utilization rate in the foetal sheep as a function of glucose and insulin concentrations using a three-dimensional analogue of the Michaelis-Menten pharmacokinetic model. To account for multiple measurements per sheep, we apply the non-linear mixed effects model proposed by Lindstrom and Bates using the EM algorithm computational scheme presented by Hirst et al.

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