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A generalized concept of power helped to choose optimal endpoints in clinical trials

✍ Scribed by George F. Borm; Gert J. van der Wilt; Jan A.M. Kremer; Gerhard A. Zielhuis

Book ID
116623000
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
213 KB
Volume
60
Category
Article
ISSN
0895-4356

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## Background Clinically relevant endpoints cannot be routinely targeted with reasonable power in a small study. Hence, proof-of-concept studies are often powered to a primary surrogate endpoint. However, in acute heart failure (AHF) effects on surrogates have not translated into clinical benefit i