A Generalized and Efficient Preparation of a Novel Class of Macrocyclic Bis(guanidines) from Cyclic Bis(carbodiimides)
✍ Scribed by Molina, Pedro; Alajarín, Mateo; Sánchez-Andrada, Pilar; Sanz-Aparicio, Juliana; Martínez-Ripoll, Martín
- Book ID
- 127035801
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 119 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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The hydroxy macrocycles 8, 19a-c were prepared in 40-55% yields by reacting the dipotassium salts 2a-c with each of epichlorohydrin (7) and bis(chloromethyl) derivative 18. Acylation of the hydroxyl group of each of 8, 19a-c with 2-chloroacetylchloride (9) in DMF gave the corresponding esters 10, 20