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A generalization of Metabolic Control analysis to conditions of no proportionality between activity and concentration of enzymes

✍ Scribed by Enrique Meléndez-Hevia; Néstor V. Torres; Joaquín Sicilia

Book ID
104154728
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
422 KB
Volume
142
Category
Article
ISSN
0022-5193

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✦ Synopsis

The assumption currently considered in the Metabolic Control Theory that velocity of every isolated step is proportional to enzyme concentration, is analysed by considering that in some metabolic systems that condition could not be accomplished. Analysis of the main core of this theory is carried out removing this hypothesis, expressed as "e~l is not necessarily equal to one". The results obtained supply a more general formulation of the main theorems of the Control Theory, extending its possible application to more complex metabolic systems. OF METABOLIC CONTROL ANALYSIS 445

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Both experimental and theoretical studies of metabolism are likely to relate to a segment that has been isolated for analytical purposes. In practice, it will be embedded in the whole of cellular metabolism. Thus, it is necessary to consider how conclusions about the control of an isolated pathway m