β Scribed by Sungchul Ji
No coin nor oath required. For personal study only.
To define the molecular processes underlying toxicological manifestations experimentally measured on the cellular level, it is essential to have available a molecular model of the living cell itself. The Bhopalator is a molecular model of the living cell formulated by integrating the three major branches of biology within a coherent theoretical framework - the Watson-Crick molecular genetics, the conformon theory of enzymic catalysis, and the theory of dissipative structures developed by I. Prigogine. According to this model, the living cell is a self-moving, self-thinking and self-reproducing machine (automaton) that receives information and energy from its environment, processes them according to the genetic programs stored in DNA, and generates output signals to environment in order to realize teleonomically designed functions. The Bhopalator suggests a set of general statements useful in toxicological research, and these statements have been utilized to provide possible answers to several fundamental questions raised by recent experimental findings on chemically-induced cell injury and death.
π SIMILAR VOLUMES
Consideration is given to the development of a general theory for the determination of the structure in the vicinity of the tip of a crack within an isotropic elastic solid. The basis of the model is the presence of a Barenhlatt-type zone, in which cohesive stresses act, thereby allowing non-linear