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A general synthesis of 8-hydroxy-6-substituted-1,7-naphthyridines

✍ Scribed by Xinglong Jiang; Guang-Pei Chen; Kapa Prasad; Oljan Repič; Thomas J. Blacklock

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 220 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430648

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✦ Synopsis

Abstract

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A general method for the synthesis of 8‐hydroxy‐6‐substituted‐1,7‐naphthyridines is described using acylation of the dianion derived from tert‐butylamide 1, followed by cyclization of the resulting intermediate ketones 2 with ammonium acetate.

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