A general synthesis of 2-formyl-3-arylpyrroles
✍ Scribed by Cécile Franc; Frédéric Denonne; Claire Cuisinier; Léon Ghose
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 217 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
2-Formyl-3-iodo-l-tosylpyrrole 2 has been prepared in four steps from cinnamaldehyde. It was coupled with a wide variety of arylboronic acids to give the corresponding blaryl compounds in high yields.
📜 SIMILAR VOLUMES
Reactim of methyl azidoacetate with B-arylacroleins, follmd by cyclisati~ of the cbtained derivatives easily leads to arylpyrroles. N M R and ness spectra data are given and the Vilsmeier fomylation of sorts arylpyrroles is described.
53 51 49 48 54 \*Compounds Id, e were separated chromatographically on a silica-gel column using hexane eluent. \*\*Yield based on compounds IIa-c.
## Pyrazole derivatives R 0180 Synthesis and Antimicrobial Activity of 2-(4-Formyl-3-pyrazolyl)-3-phenylindoles. -Vilsmeier-Haack reaction of hydrazones (VI) followed by alkaline hydrolysis furnishes title compounds (VIII). These and their azines (X) are tested for their antimicrobial and antifung