A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group

Concise Synthesis of [1,1′-Biisoquinolin

Concise Synthesis of [1,1′-Biisoquinoline]-4,4′-diol via a Protecting Group Strategy and Its Application for Potential Liquid-Crystalline Compounds

✍ Elisabeth Kapatsina; Markus Mateescu; Angelika Baro; Wolfgang Frey; Sabine Lasch 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 263 KB

## Abstract The [1,1′‐biisoquinoline]‐4,4′‐diol (**4a**), which was obtained as hydrochloride **4a**⋅2 HCl in two steps starting from the methoxymethyl (MOM)‐protected 1‐chloroisoquinoline **8** (__Scheme 3__), opens access to further O‐functionalized biisoquinoline derivatives. Compound **4a**⋅2 H