A general, stereocontrolled entry to pyrimidine homo-C-nucleosides
โ Scribed by T. Sato; K. Marunouchi; R. Noyori
- Book ID
- 104246490
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 234 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
A simple synthesis of nucleoside analogues with a methylene group between the ribose and B-position of pyrimidine appendages is outlined.
The unique activities displayed by the homonucleotides I and II2 prompted us to prepare homo -C-nucleosides,
๐ SIMILAR VOLUMES
Novel dithiotosylate-mediated C-C ring scission reactions l-t2 and 24+5 conve--niently made available synthons towards a host of carbocyclic analogs-o? C-nucleosides. Unlike the past work,4 no chemoselectivity problems arose in generation of 15. -The broad spectrum C-nucleoside antibiotics produced
4-Thio furanoid glycals with different types of O-silyl protection have been prepared from benzyl 3,5-di-O-benzyl-2-deoxy-l,4-dithio-D-erythro-pentofumnoside. Face-selectivity for PhSeCI-or N-iodosuecimide-initiated addition of a pyrimidine base to the thioglycal was found to be controlled by O-sily