β Scribed by M Jainz
No coin nor oath required. For personal study only.
The program estimates the optimal gene-frequencies from observed values of phenotypes by the method of maximumlikelihood. The program does not make assumptions about a specific blood-group-system. This information has to be supplied by input cards.
A straightforward iteration process is used for obtaining initial estimates for the gene-frequencies in question. Then an iterative application of the Newton-Raphson method is used to solve the maximum-likelihood equations.
The program yields the gene-frequencies and their standard deviations, expected values of the phenotypes, expected values of the genotypes. Finally the ehi-square between observed frequencies and (optimal) expected values of phenotypes is computed.
π SIMILAR VOLUMES
An operator-interactive curve-fitting procedure developed for the PDP 1 l/70 minicomputer is described. The multiexponential fitting function that can be applied to data obeying Poisson fluctuations may contain the sum of up to four exponential terms. The best estimates of the parameters and their e
## Abstract Computations attributed to the Malinowski __F__βtest are incorrect because they were based on determining the equality of secondary eigenvalues instead of the equality of reduced eigenvalues as prescribed in the original work of Malinowski. When the correct expression was employed, the
## Abstract Single nucleotide polymorphisms (SNPs) are important markers to investigate genetic heterogeneity of population and to perform linkage disequilibrium (LD) mapping. We propose a new method, Ξ¨, to express frequency of 2 haplotypes for __N~s~__ diβallelic SNPs. Using the new expression of