A General Method for the Synthesis of t-Butyl Esters
β Scribed by Abramovitch, B.; Shivers, J. C.; Hudson, B. E.; Hauser, C. R.
- Book ID
- 127312382
- Publisher
- American Chemical Society
- Year
- 1943
- Tongue
- English
- Weight
- 120 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0002-7863
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## Swnmary: T-butyl 2,2,2-trichloroaceiimi&e (l), reaa?ly prepared by addition of t-butawl to trichloroacetonitrile, is an efficient reagent for the preparation of t-butyl ethers and esters in the presence of a catalytic amount of boron trifhon& etherate. Traditional methods for the preparation of
A method for the cleavage of t-butyl esters using silica gel in refluxing toluene is reported. Good yields of the corresponding carboxylic acids are obtained, and the reaction is selective for t-butyl esters over t-butyl ethers and trimethylsilylethyl (TMSE) esters.