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A general method for the purification of synthetic oligodeoxyribonucleotides containing strong secondary structure by reversed-phase high-performance liquid chromatography on PRP-1 resin

โœ Scribed by Markus W. Germann; Richard T. Pon; Johan H. van de Sande

Book ID
107714453
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
701 KB
Volume
165
Category
Article
ISSN
0003-2697

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โœ M.B. Arghavani; L.J. Romano ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 595 KB

Synthetic oligodeoxyribonucleotides containing a high guanine content have a tendency to form intra- or intermolecular complexes in solution make HPLC purification difficult or sometimes impossible. We have developed a simple method that has enabled us to purify a series of highly guanine-rich and s