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A GENERAL METHOD FOR ACYLATION OF 1,3-DIALKYL-SUBSTITUTED BARBITURIC AND 2-THIOBARBITURIC ACIDS

✍ Scribed by Strekowski, Lucjan; Ismail, Mohamed A.; Zoorob, Hanafi H.


Book ID
118262641
Publisher
Walter de Gruyter GmbH & Co. KG
Year
1999
Tongue
English
Weight
248 KB
Volume
5
Category
Article
ISSN
0793-0283

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Synthesis of 5-(functionalized acyl)-1,3
✍ Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski πŸ“‚ Article πŸ“… 2001 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 53 KB

## Abstract A sodium derivative of 1,3‐dimefhylbarbituric acid or 1,3‐diethyl‐2‐thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ω‐chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor