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A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer?

โœ Scribed by Domenico Palli; Giovanna Masala; Renato Mariani-Costantini; Ines Zanna; Calogero Saieva; Francesco Sera; Adriano Decarli; Laura Ottini


Book ID
116428304
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
263 KB
Volume
40
Category
Article
ISSN
0959-8049

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BRCA1 and BRCA2 mutations in Russian fam
โœ Irina V. Tereschenko; Victoria M. Basham; Bruce A.J. Ponder; Paul D.P. Pharoah ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 24 KB ๐Ÿ‘ 2 views

We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie