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A GATA-3 binding site in the first intron of the interleukin-4 gene defines a critical element for the memory expression of interleukin-4 in Th lymphocytes

✍ Scribed by L Tykocinski, P Hajkova, T Stamm, O Sözeri, M Löhning, B Friedrich…


Book ID
120707971
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
595 KB
Volume
5
Category
Article
ISSN
1478-6354

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## Abstract In Th1 and Th2 memory lymphocytes, the genes for the cytokines interleukin (IL)‐4 and interferon‐γ (IFN‐γ) are imprinted for expression upon restimulation. This cytokine memory is based on expression of the transcription factors T‐bet for IFN‐γ, and GATA‐3 for IL‐4, and epigenetic modif