✦ LIBER ✦
A galabiose-based two-dimensional scaffold for the synthesis of inhibitors targeting Pk- and P-antigen binding proteins
✍ Scribed by Jörgen Ohlsson; Ulf J. Nilsson
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 178 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A disaccharide scaffold based on galabiose (Gala1-4Gal) was synthesized. Four different acceptors were evaluated in the a-galactosylation and a relationship between the nucleophilicity, yield, and a/b-selectivity was found. The scaffold contains two orthogonal derivatisation sites, i.e. at O-2% and the anomeric position, and as proof of concept, one derivatised galabioside was synthesized. Compounds based on this galabiose-scaffold are potential inhibitors of P-and P k -antigen binding proteins.