A G-CSF Receptor–Gyrase B Fusion Gene: A New Type of Molecular Switch for Expansion of Genetically Modified Hematopoietic Cells

In vivo expansion of gene-modified hemat

In vivo expansion of gene-modified hematopoietic cells by a novel selective amplifier gene utilizing the erythropoietin receptor as a molecular switch

✍ Takeyuki Nagashima; Yasuji Ueda; Yutaka Hanazono; Akihiro Kume; Hiroaki Shibata; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 314 KB 👁 1 views

## Abstract ## Background __In vivo__ expansion of gene‐modified cells would be a promising approach in the field of hematopoietic stem cell gene therapy. To this end, we previously developed a selective amplifier gene (SAG), a chimeric gene encoding the granulocyte colony‐stimulating factor (G‐CS