𝔖 Bobbio Scriptorium
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A functionally distinct member of the DP family of E2F subunits

✍ Scribed by Milton, A; Luoto, K; Ingram, L; Munro, S; Logan, N; Graham, A L; Brummelkamp, T R; Hijmans, E M; Bernards, R; La Thangue, N B


Book ID
110070365
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
210 KB
Volume
25
Category
Article
ISSN
0950-9232

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Differential activities of E2F family me
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Several regulators of E2F transcriptional activity, including the retinoblastoma tumor suppressor (Rb) protein, p16 Ink4a , cyclin D1, and cyclin-dependent kinase 4, have been shown to be targets for genetic alterations that underlie the development of human cancers. Deregulation of E2F transcriptio