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A functional variant in the promoter region regulates the C-reactive protein gene and is a potential candidate for increased risk of atrial fibrillation

✍ Scribed by S.-N. Chang; C.-T. Tsai; C.-K. Wu; J.-K. Lee; L.-P. Lai; S.-W. Huang; L.-Y. Huang; C.-D. Tseng; J.-L. Lin; F.-T. Chiang; J.-J. Hwang

Book ID
114742997
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
276 KB
Volume
272
Category
Article
ISSN
0954-6820

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th