A functional variant in the CFI gene confers a high risk of age-related macular degeneration
✍ Scribed by van de Ven, Johannes P H; Nilsson, Sara C; Tan, Perciliz L; Buitendijk, Gabriëlle H S; Ristau, Tina; Mohlin, Frida C; Nabuurs, Sander B; Schoenmaker-Koller, Frederieke E; Smailhodzic, Dzenita; Campochiaro, Peter A; Zack, Donald J; Duvvari, Maheswara R; Bakker, Bjorn; Paun, Codrut C; Boon, Camiel J F; Uitterlinden, Andre G; Liakopoulos, Sandra; Klevering, B Jeroen; Fauser, Sascha; Daha, Mohamed R; Katsanis, Nicholas; Klaver, Caroline C W; Blom, Anna M; Hoyng, Carel B; den Hollander, Anneke I
- Book ID
- 120494809
- Publisher
- Nature Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 902 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng.2640
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Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing)