𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis

✍ Scribed by Alexandra Nieters; Paige M. Bracci; Silvia de Sanjosé; Nikolaus Becker; Marc Maynadié; Yolanda Benavente; Lenka Foretova; Pierluigi Cocco; Anthony Staines; Elizabeth A. Holly; Paolo Boffetta; Paul Brennan; Christine F. Skibola

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
281 KB
Volume
128
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (−1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with non‐Hodgkin lymphoma (NHL) risk was replicated in a European multicenter study of 855 NHL cases and 1,206 controls. In the combined analysis of 2,617 cases and 3,605 controls, carrying the TT genotype was associated with an increased risk for all NHL (OR = 1.4; p for linear trend = 0.00009), diffuse large B‐cell lymphoma (OR = 1.6; p for linear trend = 0.002) and follicular lymphoma (OR = 1.6; p for linear trend = 0.001). These data suggest a possible role of this functional polymorphism in lymphomas originating within the germinal center.

📜 SIMILAR VOLUMES

Personal sun exposure and risk of non Ho
Personal sun exposure and risk of non Hodgkin lymphoma: A pooled analysis from the Interlymph Consortium
✍ Anne Kricker; Bruce K. Armstrong; Ann Maree Hughes; Chris Goumas; Karin Ekström 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 232 KB

## Abstract In 2004–2007 4 independent case‐control studies reported evidence that sun exposure might protect against NHL; a fifth, in women only, found increased risks of NHL associated with a range of sun exposure measurements. These 5 studies are the first to examine the association between pers

Non-Hodgkin lymphoma and obesity: A pool
Non-Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph Consortium
✍ Eleanor V. Willett; Lindsay M. Morton; Patricia Hartge; Nikolaus Becker; Leslie 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 550 KB

## Abstract Nutritional status is known to alter immune function, a suspected risk factor for non‐Hodgkin lymphoma (NHL). To investigate whether long‐term over, or under, nutrition is associated with NHL, self‐reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,00

Obesity and risk of non-Hodgkin's lympho
Obesity and risk of non-Hodgkin's lymphoma: A meta-analysis
✍ Susanna C. Larsson; Alicja Wolk 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 331 KB

## Abstract Obesity is associated with altered immune and inflammatory responses and it may therefore influence the risk of non‐Hodgkin's lymphoma. However, epidemiologic findings on obesity in relation to non‐Hodgkin's lymphoma have been inconsistent. We conducted a meta‐analysis to summarize the

Pregnancy and risk of non-Hodgkin's lymp
Pregnancy and risk of non-Hodgkin's lymphoma: A prospective study
✍ Hans-Olov Adami; Shirng-wern Tsaih; Mats Lambe; Chung-cheng Hsieh; Johanna Adami 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 37 KB 👁 2 views

The etiology of non-Hodgkin's lymphomas (NHL), including chronic lymphocytic leukemia (CLL), is likely to be related to immune function. In the light of the established immunologic effects of a pregnancy, we decided to examine the risk of NHL and CLL in relationship to full-term pregnancies. Within