A functional test of Neandertal and modern human mitochondrial targeting sequences
✍ Scribed by Matthias Gralle; Ingo Schäfer; Peter Seibel; Svante Pääbo
- Book ID
- 116301006
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 539 KB
- Volume
- 402
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Neandertals, the archaic human form documented in Eurasia until 29,000 years ago, share no mitochondrial haplotype with modern Europeans. Whether this means that the two groups were reproductively isolated is controversial, and indeed nuclear data have been interpreted as suggesting tha
## Abstract Citrate synthase (CS), the first and rate‐limiting enzyme of the tricarboxylic acid (TCA) cycle, plays a decisive role in regulating energy generation of mitochondrial respiration. Most mitochondrial proteins are synthesized in the cytoplasm as preproteins with an amino (N)‐terminal mit