✦ LIBER ✦

A functional factor X deficiency

✍ Scribed by Paul Sun; Jane Hata; John Bauer; Carolyn Haibach; Doug Campbell; Medhi Farhangi; Dan Smith

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 584 KB
Volume: 48
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830480102

No coin nor oath required. For personal study only.

✦ Synopsis

Afunctional factor X deficiency is described which caused pronounced reduction in the in vitro activation of the extrinsic system while marginally affecting the in vitro activation of the intrinsic pathway. All studies were normal with the exception of a prolonged PT, an elevated factor X antigen, and low factor X activity. Western blot analysis revealed the presence of two factor X species. The abnormal molecule was of higher molecular weight. Interestingly, there was no bleeding associated with this deficiency. The biochemical basis of this defect is currently under investigation.

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