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A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer

โœ Scribed by Bin Liu; Lei Yang; Binfang Huang; Mei Cheng; Hui Wang; Yinyan Li; Dongsheng Huang; Jian Zheng; Qingchu Li; Xin Zhang; Weidong Ji; Yifeng Zhou; Jiachun Lu


Book ID
119184355
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
284 KB
Volume
91
Category
Article
ISSN
0002-9297

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## Abstract Activation of oncogenic __Kras__ in murine lung leads to the development of numerous small adenomas, only some of which progress over time to overt adenocarcinoma. Thus, although __Kras__ is the initiating oncogene, it is likely that secondary genetic events are required for progression