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A functional complement system is required for normal T helper cell differentiation

✍ Scribed by Pirkka T. Pekkarinen; Kirsi Vaali; Sami Junnikkala; Laura H. Rossi; Heli Tuovinen; Seppo Meri; Outi Vaarala; T. Petteri Arstila

Book ID
116569577
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
247 KB
Volume
216
Category
Article
ISSN
0171-2985

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## Abstract Notch1 proteins are involved in binary cell fate decisions. To determine the role of Notch1 in the differentiation of CD4^+^ Th1 versus Th2 cells, we have compared T helper polarization __in vitro__ in naive CD4^+^ T cells isolated from mice in which the N1 gene is specifically inactiva