A functional assessment of macrophages from osteopetrotic mice

✍ Scribed by T. J. Chambers; J. F. Loutit

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 639 KB
• Volume: 129
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/path.1711290203

✦ Synopsis

Macrophages from osteopetrotic mice caused less bone resorption than normal sib macrophages in culture. The bone-resorbing activity lay in the culture supernatant, and reduced activity in cultures of macrophages from osteopetrotic mice correlated with reduced glass spreading and reduced latex phagocytosis. We suggest that macrophages from osteopetrotic mice show defective phagocytic recognition of glass, latex, and bone and that this defective recognition may reflect the cause of the failure of resorption which results in osteopetrosis.