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A functional alternative splicing mutation in human tryptophan hydroxylase-2

✍ Scribed by Zhang, X; Nicholls, P J; Laje, G; Sotnikova, T D; Gainetdinov, R R; Albert, P R; Rajkowska, G; Stockmeier, C A; Speer, M C; Steffens, D C

Book ID
109890211
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
475 KB
Volume
16
Category
Article
ISSN
1359-4184

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Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Several variants of human TPH2 have been reported to be associated with a spectrum of neuropsychiatric disorders such as unipolar major depression, bipolar disorder, suicidality, and att