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A Free-Energy Relationship between the Rate of Acidic Hydrolysis of Glycosides and the pKa of Isofagomines

✍ Scribed by Henrik H. Jensen; Laila Lyngbye; Mikael Bols


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
74 KB
Volume
113
Category
Article
ISSN
0044-8249

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The acid unfolding of deoxymyoglobin (deoxyMb) from the native (N) form to the unfolded (U) form proceeds through at least two spectroscopically distinct heme intermediates. The 426-nm absorbing heme intermediate ( I-form) occurs in the pH Γ‡ 3.5-4.5 range. In the I-form, the iron-proximal histidine