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A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

โœ Scribed by Dingerdissen, Hayley; Weaver, Daniel S; Karp, Peter D; Pan, Yang; Simonyan, Vahan; Mazumder, Raja


Book ID
125402272
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
956 KB
Volume
9
Category
Article
ISSN
1745-6150

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โœ Evelyn D. Lobo; David M. Soda; Joseph P. Balthasar ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 263 KB

We have shown that intravenous (i.v.) administration of anti-methotrexate (MTX) antibodies (AMAb) reduces the systemic exposure of intraperitoneal (i.p.) MTX therapy, and we have proposed that AMAb effects on MTX systemic exposure would allow a reduction in MTX-induced systemic toxicity (i.e., produ