## Abstract Germβline mutations within __BRCA1__ are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of __BR
A founder BRCA2 mutation in non-Afrikaner breast cancer patients of the Western Cape of South Africa
β Scribed by NC van der Merwe; N Hamel; S-R Schneider; JP Apffelstaedt; JT Wijnen; WD Foulkes
- Book ID
- 110889217
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 579 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0009-9163
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have investigated the impact of BRACA1 and BRACA2 mutations that were frequently identified among Hungarian high-risk breast-ovarian cancer families (Ramus et al., 1997b, AJHG), on the development of breast and ovarian cancer in the general Hungarian population. The prevalence of 3 BRCA1 mutation
The 185delAG and 5382insC founder mutations account for the majority of mutations identified in BRCA1 in Ashkenazi Jewish breast and breast-ovarian cancer families. Few non-founder BRCA1 mutations have been identified to date in these families. We initially screened a panel of 245 Ashkenazi Jewish b